Dynamic changes in murine vessel geometry assessed by high-resolution magnetic resonance angiography: a 9.4 T study. First performance evaluation of a dual-source CT (DSCT) system. High-resolution structural and functional assessments of cerebral microvasculature using 3D gas ΔR2*-mMRA.
Digital reconstruction and morphometric analysis of human brain arterial vasculature from magnetic resonance angiography.
Comparison of CT and CT angiography source images with diffusion-weighted imaging in patients with acute stroke within 6 hours after onset. Heart disease and stroke statistics-2013 update-a report from the American Heart Association. An imaging rate of ∼5.3 frames per second allows for dynamic recording of blood perfusion in the cerebral vessels with sufficient temporal resolution, providing real-time assessment of a blood flow anomaly in a mouse middle cerebral artery occlusion stroke model. Reduced photon scattering in this spectral region allows fluorescence imaging to a depth of >2 mm in mouse brain with sub-10-μm resolution. Here, we report through-scalp and through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy, utilizing the intrinsic photoluminescence of single-walled carbon nanotubes in the 1.3–1.4 μm near-infrared window (NIR-IIa window).
SKULL IMAGING WINDOWS
Fluorescence-based brain imaging in the visible and traditional near-infrared regions (400–900 nm) is an alternative, but at present it requires craniotomy, cranial windows and skull-thinning techniques, and the penetration depth is limited to 1–2 mm due to light scattering. To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography, with their limited spatial resolution and long scanning times.